Monday 3rd September 2018

09:00 – 09:10 Welcome: Alfonso Martinez Arias – Department of Genetics, University of Cambridge
Session I: Controlling the Self-Engineering of Organs and Tissues

Chair: Alfonso Martinez Arias (Department of Genetics, University of Cambridge)

09:10 – 10:00 Keynote EMBO Lecture: Elly Tanaka – IMP, Vienna Austia

Signalling the self-organization of neuroepithelia

10:00 – 10:30 Paola Arlotta – University of Harvard, Boston, USA

“Human brain development and disease: from the embryo to brain organoids.”

10:30 – 11:00 Coffee Break
11:00 – 11:15 David Tourigny – Columbia University Medical Center, USA

“Energetic substrate availability regulates synchronous activity in an excitatory neural network”

11:15 – 11:30 Tiago Rito – Rockefeller University, New York, USA

“Self-organizing human neuruloids allow disease modeling in the developing ectodermal compartment”

11:30 – 12:00 Madeline Lancaster – Lab. Molecular Biology, Cambridge, UK

“Engineering functional neuronal connectivity in brain organoids”

12:00 – 12:30 Orly Reiner – The Weizmann Institute, TelAviv, Israel

“Human brain organoids on a chip to study development and disease”

12:30 – 13:00 Medicine by Design talk: Penney Gilbert – IBBME, University of Toronto, Canada

“3D culture models to study human skeletal muscle biology”

13:00 Lunch and posters
eLife Sponsored Early Career Session

Chair: Sophie Morgani (Sloan Kettering Institute, USA and University of Cambridge, UK)

14:30 – 14:45 Christian Schroeter – Max Planck Institute of Molecular Physiology, Dortmund, Germany

Emergence and maintenance of fate decisions through intercellular communication

14:45 – 15:00 Andrea Manfrin – EPFL Lausanne, Switzerland

“Engineered signalling centres for the spatiotemporal controlled patterning of human pluripotent stem cells”

15:00 – 15:15 Berna Sozen – Department of PDN, Univeristy of Cambridge, UK

“Reconstituting embryogenesis and mimicking gastrulation in vitro by spontaneous assembly of embryonic and extraembryonic stem cells”

15:15 – 15:30 Leonardo Morsut – University of Southern California, Los Angeles, USA

“Programming self-organizing multicellular structures with synthetic cell-cell signaling”

15:30 – 16:00 Coffee break and posters
Session II: Cell Ensembles: The Elements and Tools of Self-Engineering

Chair: Matthias Lutolf (EPFL, Lusanne, Switzerland)

16:00 – 16:30 Stas Shvartsman – Princeton University, USA

“Collective growth in a small cell network”

16:30 – 17:00 Barbara Treutlein – MPI, Leipzig, Germany

“Single-cell transcriptomic dissection of cerebral organoids”

17:00 – 17:30 Prisca Liberali – FMI, Basel, Switzerland

“Self-organization and symmetry breaking in intestinal organoids development”

17:30 – 18:00 Alexander van Oudenaarden – Hubrecht Institute – KNAW, University Medical Center Utrecht & Utrecht University

Whole-organism clone-tracing using single-cell sequencing”

18:00 – 19:30 Poster session and reception drinks
20:00 Speakers dinner

Tuesday 4th September 2018

Session III: The Dynamic and Functional Organisation of Cells in Ensembles

Chair: Jenny Nichols (Stem Cell Institute, University of Cambridge)

09:30 – 10:00 Silvia Santos – The Crick Institute, London, UK

“Decoding cellular signals during commitment to ESC differentiation”

10:00 – 10:30 Carl-Philipp Heisenberg – IST, Vienna, Austria

“The role of rigidity phase transition in tissue spreading during zebrafish gastrulation”

10:30 – 11:00 Coffee break and posters
11:00 – 11:30 Virgile Viasnoff – MBI National University, Singapore

“Morphogenesis of bile canaliculi at the single cell level.”

11:30 – 11:45 Luigi Aloia – Gurdon Institute, University of Cambridge, UK

“Adult liver  cholangyocytes require optimal levels of TET1 to be reprogrammed to a proliferative stem/progenitor state”

11:45 – 12:00 Susanne van den Brink – Hubrecht Institute, The Netherlands

“Spatial transcriptomics and single cell RNAseq reveal spatial organization in gastruloid

12:00 – 12:30 Jérôme Gros – Institut Pasteur, Paris, France

“Mechanical control of gastrulation movements and Emergence of tissue fluidization by cell division”

12:30 Lunch and posters
Session IV: Embryonic Stem Cells: The Embryo Redux

Chair: Shahragim Tajbakhsh (Institute Pasteur)

14:00 – 14:30 Eric Siggia – Rockefeller University, New York, USA

Exploring embryonic patterning with structured colonies of hESC in two and three dimensions”

14:30 – 15:00 Jianping Fu – University of Michigan, USA

“Programmable microfluidic synthesis of synthetic human embryo-like entities”

15:00 – 15:30 Coffee break
15:30 – 16:00 Olivier  Pourquié – University of Harvard, Boston, USA

“Deconstructing the segmentation clock in vitro”

16:00 – 16:45 Keynote: Kat Hadjantonakis – Sloan Kettering, New York, USA

“Gastrulation in the mouse embryo – can in vitro differentiation of pluripotent stem cells tell us anything new?”